What it is
ARA-290, also called cibinetide, is an EPO-derived tissue-protective peptide studied for neuropathic pain and small fiber nerve loss.
Evidence boundary
Investigational / limited human evidence.
Trial evidence
- PMID 25387363 — ARA 290, a nonerythropoietic peptide engineered from erythropoietin, improves metabolic control and neuropathic symptoms in patients with type 2 diabetes.
- PMID 24136731 — ARA 290 improves symptoms in patients with sarcoidosis-associated small nerve fiber loss and increases corneal nerve fiber density.
- PMID 28475703 — Cibinetide Improves Corneal Nerve Fiber Abundance in Patients With Sarcoidosis-Associated Small Nerve Fiber Loss and Neuropathic Pain.
- PMID 24555851 — ARA 290 for treatment of small fiber neuropathy in sarcoidosis.
Preparation and measurement
Reconstitution: 16 mg vial + 2 mL BAC = 8 mg/mL.
Concentration matches.
Reference schedule
| Phase | Dose | Draw / measure | Frequency | Weekly total |
|---|---|---|---|---|
| Week 1 (titration) | 2 mg | 25 U (0.25 mL) | Daily during cycle | 14 mg/week |
| Weeks 2–8 (target) | 4 mg | 50 U (0.5 mL) | Daily during cycle | 28 mg/week |
Week 1 (titration)
- Dose
- 2 mg
- Draw / measure
- 25 U (0.25 mL)
- Frequency
- Daily during cycle
- Weekly total
- 14 mg/week
Weeks 2–8 (target)
- Dose
- 4 mg
- Draw / measure
- 50 U (0.5 mL)
- Frequency
- Daily during cycle
- Weekly total
- 28 mg/week
Weekly totals apply only during the active phase.
Titration rules
-
Standard (4 mg/day): Phase 2 trial dose.
-
Cycle: 28 days active per Phase 2 protocol; longer protocols (8–12 weeks) used in chronic-condition research.
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Neuropathic pain or numbness
-
Corneal nerve fiber symptoms in sarcoidosis
-
Tolerability
-
Injection-site reactions
Practical rules
- Rotate sites if it is being compared in notes.
- Don’t expand it into erythropoietic use.
Related protocols
KPV Peptide Protocol & DosingBPC-157 Peptide Protocol & DosingGHK-Cu Peptide Protocol & DosingLL-37 Peptide Protocol & Dosing Supply & lot verification
Availability and batch-linked COA records for ARA-290 Peptide Protocol & Dosing are kept with the current product listing.
View availability & COA → Verification notes