What it is
Mechano Growth Factor (MGF) is a splice-variant idea tied to IGF-1 signaling and mechanical loading. It is discussed in muscle-repair research, but human protocol data are not established.
Evidence boundary
Preclinical / speculative. Do not present a human dosing schedule as an established standard.
Trial evidence
No verified human trial found.
Preparation and measurement
Reconstitution: 5 mg vial + 3 mL BAC = 1.67 mg/mL.
Concentration matches.
Reference schedule
| Phase | Dose | Draw / measure | Frequency | Weekly total |
|---|---|---|---|---|
| Week 1 (titration) | 100 mcg | 6 U (0.06 mL) | Once daily | 700 mcg/week |
| Week 2 | 150 mcg | 9 U (0.09 mL) | Once daily | 1.05 mg/week |
| Week 3 | 200 mcg | 12 U (0.12 mL) | Once daily | 1.4 mg/week |
| Week 4 | 250 mcg | 15 U (0.15 mL) | Once daily | 1.75 mg/week |
| Weeks 5–8 (target) | 300 mcg | 18 U (0.18 mL) | Once daily | 2.1 mg/week |
Week 1 (titration)
- Dose
- 100 mcg
- Draw / measure
- 6 U (0.06 mL)
- Frequency
- Once daily
- Weekly total
- 700 mcg/week
Week 2
- Dose
- 150 mcg
- Draw / measure
- 9 U (0.09 mL)
- Frequency
- Once daily
- Weekly total
- 1.05 mg/week
Week 3
- Dose
- 200 mcg
- Draw / measure
- 12 U (0.12 mL)
- Frequency
- Once daily
- Weekly total
- 1.4 mg/week
Week 4
- Dose
- 250 mcg
- Draw / measure
- 15 U (0.15 mL)
- Frequency
- Once daily
- Weekly total
- 1.75 mg/week
Weeks 5–8 (target)
- Dose
- 300 mcg
- Draw / measure
- 18 U (0.18 mL)
- Frequency
- Once daily
- Weekly total
- 2.1 mg/week
Weekly totals apply only during the active phase.
Titration rules
- Daily titration (subcutaneous):
- Week 1 (titration): 100 mcg/day.
- Week 2: 150 mcg/day.
- Week 3: 200 mcg/day.
- Week 4: 250 mcg/day.
- Weeks 5–8 (target): 300 mcg/day. Common maintenance dose.
- Cycle: 8–12 weeks daily; optional extension to 16 weeks.
- Timing: Post-workout dosing anecdotally favored to amplify mechanical-stress signaling. PEG-MGF (different peptide) offers extended-duration alternative.
Cycle length and breaks
Timing: Post-workout dosing anecdotally favored to amplify mechanical-stress signaling.
What to monitor
- Whether a source is actually human data
- Muscle-repair claims in the source literature
- Limited safety information
- Injection-site reactions
Practical rules
- Do not use animal-model dosing as human guidance.
- Rotate sites.
- Pair any muscle-repair work with resistance training, protein, and sleep.