What it is
Cortagen is a short peptide bioregulator from the Khavinson-style literature.
Evidence boundary
Regional literature only. Not a validated standard.
Trial evidence
- PMID 21476278 — [Cortexin and cortagen as correcting agents in functional and metabolic disorders in the brain in chronic ischemia].
- PMID 15159690 — Elucidation of the effect of brain cortex tetrapeptide Cortagen on gene expression in mouse heart by microarray.
- PMID 11276314 — Effect of tetrapeptide cortagen on regeneration of sciatic nerve.
- PMID 37042594 — EPIGENETIC MODIFICATION UNDER THE INFLUENCE OF PEPTIDE BIOREGULATORS ON THE “OLD” CHROMATIN.
Preparation and measurement
Reconstitution: 20 mg vial + 3 mL BAC = 6.67 mg/mL.
Concentration matches.
Reference schedule
| Phase | Dose | Draw / measure | Frequency | Weekly total |
|---|---|---|---|---|
| Days 1–20 (cycle on) | 500 mcg | 7.5 U (0.075 mL) | Once daily during cycle (20 days on / 4–6 months off) | 3.5 mg/week |
| Months 1–6 (cycle off) | 0 mcg | 0 U (no draw) | Off | 0 |
Days 1–20 (cycle on)
- Dose
- 500 mcg
- Draw / measure
- 7.5 U (0.075 mL)
- Frequency
- Once daily during cycle (20 days on / 4–6 months off)
- Weekly total
- 3.5 mg/week
Months 1–6 (cycle off)
- Dose
- 0 mcg
- Draw / measure
- 0 U (no draw)
- Frequency
- Off
- Weekly total
- 0
Weekly totals apply only during the active phase.
Titration rules
-
Days 1–20 (cycle on): 500 mcg/day. Once daily during the 20-day active phase.
-
Cycle structure: 20-day active phase, 4–6 month rest. 1–2 cycles per year is standard.
-
Timing: Once daily during active phase; time of day flexible. Rotate injection sites.
-
Cognitive or neural support claims in the literature
-
Tolerability
-
Injection-site reactions
Practical rules
- Rotate sites only if any injection note is being reviewed.
Related protocols
Chonluten Peptide Protocol & DosingVilon Peptide Protocol & DosingCerebrolysin Peptide Protocol & DosingPinealon Peptide Protocol & Dosing Supply & lot verification
Availability and batch-linked COA records for Cortagen Peptide Protocol & Dosing are kept with the current product listing.
View availability & COA → Verification notes