Immune / Anti-Inflammatory

Cortagen Peptide Protocol & Dosing

Updated 2mo ago 5 min read 144+ helpful Calculator

Validity Score

18 Speculative

Evidence 41

Community 35

Completeness 71

Actionability 80

Coverage 80

Penalty -34

This score combines formal evidence, page completeness, calculator readiness, and community convergence.

What it is

Cortagen is a short peptide bioregulator from the Khavinson-style literature.

Evidence boundary

Regional literature only. Not a validated standard.

Trial evidence

PMID 21476278 — [Cortexin and cortagen as correcting agents in functional and metabolic disorders in the brain in chronic ischemia].
PMID 15159690 — Elucidation of the effect of brain cortex tetrapeptide Cortagen on gene expression in mouse heart by microarray.
PMID 11276314 — Effect of tetrapeptide cortagen on regeneration of sciatic nerve.
PMID 37042594 — EPIGENETIC MODIFICATION UNDER THE INFLUENCE OF PEPTIDE BIOREGULATORS ON THE “OLD” CHROMATIN.

Preparation and measurement

Reconstitution: 20 mg vial + 3 mL BAC = 6.67 mg/mL.

Concentration matches.

Reference schedule

Reference schedule
Phase	Dose	Draw / measure	Frequency	Weekly total
Days 1–20 (cycle on)	500 mcg	7.5 U (0.075 mL)	Once daily during cycle (20 days on / 4–6 months off)	3.5 mg/week
Months 1–6 (cycle off)	0 mcg	0 U (no draw)	Off	0

Days 1–20 (cycle on)

Dose: 500 mcg
Draw / measure: 7.5 U (0.075 mL)
Frequency: Once daily during cycle (20 days on / 4–6 months off)
Weekly total: 3.5 mg/week

Months 1–6 (cycle off)

Dose: 0 mcg
Draw / measure: 0 U (no draw)
Frequency: Off
Weekly total: 0

Weekly totals apply only during the active phase.

Titration rules

Days 1–20 (cycle on): 500 mcg/day. Once daily during the 20-day active phase.
Cycle structure: 20-day active phase, 4–6 month rest. 1–2 cycles per year is standard.
Timing: Once daily during active phase; time of day flexible. Rotate injection sites.
Cognitive or neural support claims in the literature
Tolerability
Injection-site reactions

Practical rules

Rotate sites only if any injection note is being reviewed.

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Dosing references

Peptide dosage chart Peptide dose calculator Syringe mixability

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Dosing Calculator

10 mg + 2 mL BAC · week 1 500 mcg

LIVE CALCULATIONvolume / concentration / draw

RP–CALC–01

01 Vial size

02 BAC water

DRAW AMOUNT10 units0.1 mL · U-100

Draw 10 units, equivalent to 0.1 milliliters.

Concentration5 mg/mL

Selected dose0.5 mg (500 mcg) = 10 units

04 Custom dose

05 Standard amounts

1–10 mg · 0.5 mg steps

06 Suggested doses Select a row

1 unit = 0.01 mL on a U-100 syringe. Values retain decimal precision; visual marks are not silently snapped.

07 cycle summary

Vials required for Cycle

Estimate how much material you need for a full cycle, including cycle length and the number of cycles you plan to run.

Cycle length (weeks) Injections per week Number of cycles

Cycle total —

Total required vials —

Total reconstitution —

Total BAC water —

08 projected levels

How the draws stack up

A first-order model of depot absorption and elimination, run on the draws and cadence above. Pick the half-life from whatever your own source documents — this page does not assume one per compound. A planning sketch — not a prediction for any compound or any individual.

Half-life

Hours

Modelled level across the cycle. Each spike is one draw.

Accumulation—steady state vs one draw

Peak-to-trough—inside one interval

Steady state—about 4 half-lives

Draws modelled—at this cadence

Vial yieldat the selected amount

Draws per vial—

Lasts—

Volume used—

Limiting factor—

Water matrixsame vial, same amount

WaterStrengthDraw

0.5 mL——

1 mL——

2 mL——

3 mL——

5 mL——