What it is
Pinealon is a short peptide bioregulator from the Khavinson literature.
Evidence boundary
Regional literature only. Do not present it as a settled sleep or cognition standard.
Trial evidence
- PMID 24909721 — Short peptides stimulate serotonin expression in cells of brain cortex.
- PMID 25051764 — [Regulation of content of cytokines in blood serum and of caspase-3 activity in brains of old rats in model of sharp hypoxic hypoxia with Cortexin and Pinealon].
- PMID 26390612 — [EFFECT OF SYNTHETIC PEPTIDES ON AGING OF PATIENTS WITH CHRONIC POLYMORBIDITY AND ORGANIC BRAIN SYNDROME OF THE CENTRAL NERVOUS SYSTEM IN REMISSION].
- PMID 28509493 — [Pinealon and Cortexin influence on behavior and neurochemical processes in 18-month aged rats within hypoxia and hypothermia].
Preparation and measurement
Reconstitution: 20 mg vial + 3 mL BAC = 6.67 mg/mL.
Concentration matches.
Reference schedule
| Phase | Dose | Draw / measure | Frequency | Weekly total |
|---|---|---|---|---|
| Days 1–5 (titration) | 1 mg | 15 U (0.15 mL) | Once daily during cycle (10–20 days, repeat every 2–3 months) | 7 mg/week |
| Days 6–14 | 1.5 mg | 22.5 U (0.225 mL) | Once daily during cycle (10–20 days, repeat every 2–3 months) | 10.5 mg/week |
| Days 15–20 (target) | 2 mg | 30 U (0.3 mL) | Once daily during cycle (10–20 days, repeat every 2–3 months) | 14 mg/week |
Days 1–5 (titration)
- Dose
- 1 mg
- Draw / measure
- 15 U (0.15 mL)
- Frequency
- Once daily during cycle (10–20 days, repeat every 2–3 months)
- Weekly total
- 7 mg/week
Days 6–14
- Dose
- 1.5 mg
- Draw / measure
- 22.5 U (0.225 mL)
- Frequency
- Once daily during cycle (10–20 days, repeat every 2–3 months)
- Weekly total
- 10.5 mg/week
Days 15–20 (target)
- Dose
- 2 mg
- Draw / measure
- 30 U (0.3 mL)
- Frequency
- Once daily during cycle (10–20 days, repeat every 2–3 months)
- Weekly total
- 14 mg/week
Weekly totals apply only during the active phase.
Titration rules
- Days 1–5 (titration): 1.0 mg/day.
- Days 6–14: 1.5 mg/day.
- Days 15–20 (target): 2.0 mg/day.
- Cycle structure: 10–20 day active phase, 2–3 month break between cycles. Typically 1–2 cycles per year.
- Timing: Once daily during cycle, time of day flexible.
Cycle length and breaks
Timing: Once daily during cycle, time of day flexible.
What to monitor
- Do not read this as stronger than the evidence supports.
- Tolerability
- Injection-site reactions
- Regional protocol claims only
Practical rules
- Rotate sites if it is being compared in notes.
Related protocols
DSIP Peptide Protocol & DosingEpitalon Peptide Protocol & DosingCerebrolysin Peptide Protocol & DosingSelank Peptide Protocol & Dosing Supply & lot verification
Availability and batch-linked COA records for Pinealon Peptide Protocol & Dosing are kept with the current product listing.
View availability & COA → Verification notes