What it is
Ipamorelin is a selective growth-hormone secretagogue studied for GH pulse support with less cortisol or prolactin noise than older GHRPs.
Evidence boundary
Investigational / limited human evidence.
Trial evidence
- PMID 42578445 — Peptide Supplements and Their Therapeutic Applications in Sports Medicine.
- PMID 42160466 — Injectable Peptides in Sports Medicine: A Structured Narrative Review of Evidence, Safety, and Antidoping Implications.
- PMID 42123471 — Therapeutic Peptides in Aesthetic, Metabolic and Endocrine Conditions: Effects, Safety, Clinical Applications, and Future Perspectives.
Preparation and measurement
Reconstitution: 10 mg vial + 2 mL BAC = 5 mg/mL.
Concentration matches.
Reference schedule
| Phase | Dose | Draw / measure | Frequency | Weekly total |
|---|---|---|---|---|
| Weeks 1–2 (titration) | 100 mcg | 2 U (0.02 mL) | 1–3× daily | 700 mcg/week |
| Weeks 3–4 | 150 mcg | 3 U (0.03 mL) | 1–3× daily | 1.05 mg/week |
| Weeks 5–8 | 200 mcg | 4 U (0.04 mL) | 1–3× daily | 1.4 mg/week |
| Weeks 9–12 (maintenance) | 250 mcg | 5 U (0.05 mL) | 1–3× daily | 1.75 mg/week |
Weeks 1–2 (titration)
- Dose
- 100 mcg
- Draw / measure
- 2 U (0.02 mL)
- Frequency
- 1–3× daily
- Weekly total
- 700 mcg/week
Weeks 3–4
- Dose
- 150 mcg
- Draw / measure
- 3 U (0.03 mL)
- Frequency
- 1–3× daily
- Weekly total
- 1.05 mg/week
Weeks 5–8
- Dose
- 200 mcg
- Draw / measure
- 4 U (0.04 mL)
- Frequency
- 1–3× daily
- Weekly total
- 1.4 mg/week
Weeks 9–12 (maintenance)
- Dose
- 250 mcg
- Draw / measure
- 5 U (0.05 mL)
- Frequency
- 1–3× daily
- Weekly total
- 1.75 mg/week
Weekly totals apply only during the active phase.
Titration rules
- Standard (300 mcg, 2–3× daily): Common research dose.
- Cycle structure: 12–16 weeks continuous, 4-week break. Receptor desensitization is uncommon at clean ipamorelin doses but cycling is the conservative default.
- Timing: Avoid eating for 30+ min after dose. Pre-bed timing aligns with natural overnight GH pulse.
Cycle length and breaks
Receptor desensitization is uncommon at clean ipamorelin doses, but cycling is the conservative default.
What to monitor
- Sleep and recovery
- Hunger changes
- Water retention
- Injection-site reactions
Practical rules
- Pre-bed timing is common in the collected notes.
- Avoid eating right after dosing.
- Keep training and sleep steady.
- Rotate sites.
Related protocols
CJC-1295 (DAC) Peptide Protocol & DosingCJC-1295 (No DAC) Peptide Protocol & DosingGHRP-2 Peptide Protocol & DosingSermorelin Peptide Protocol & DosingTesamorelin Peptide Protocol & DosingHexarelin Peptide Protocol & DosingIbutamoren (MK-677) Peptide Protocol & Dosing Supply & lot verification
Availability and batch-linked COA records for Ipamorelin Peptide Protocol & Dosing are kept with the current product listing.
View availability & COA → Verification notes