What it is
Sermorelin is a short-acting GHRH analog studied for endogenous GH pulse support.
Evidence boundary
Investigational / limited human evidence.
Trial evidence
- PMID 42395176 — The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration.
- PMID 41490200 — Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
- PMID 41880199 — A new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodybuilding: a critical review.
Preparation and measurement
Reconstitution: 10 mg vial + 2 mL BAC = 5 mg/mL.
Concentration matches.
Reference schedule
| Phase | Dose | Draw / measure | Frequency | Weekly total |
|---|---|---|---|---|
| Weeks 1–2 (titration) | 200 mcg | 4 U (0.04 mL) | Once daily (pre-bed) | 1.4 mg/week |
| Weeks 3–4 | 300 mcg | 6 U (0.06 mL) | Once daily (pre-bed) | 2.1 mg/week |
| Weeks 5–6 | 400 mcg | 8 U (0.08 mL) | Once daily (pre-bed) | 2.8 mg/week |
| Weeks 7–8 (target) | 500 mcg | 10 U (0.1 mL) | Once daily (pre-bed) | 3.5 mg/week |
Weeks 1–2 (titration)
- Dose
- 200 mcg
- Draw / measure
- 4 U (0.04 mL)
- Frequency
- Once daily (pre-bed)
- Weekly total
- 1.4 mg/week
Weeks 3–4
- Dose
- 300 mcg
- Draw / measure
- 6 U (0.06 mL)
- Frequency
- Once daily (pre-bed)
- Weekly total
- 2.1 mg/week
Weeks 5–6
- Dose
- 400 mcg
- Draw / measure
- 8 U (0.08 mL)
- Frequency
- Once daily (pre-bed)
- Weekly total
- 2.8 mg/week
Weeks 7–8 (target)
- Dose
- 500 mcg
- Draw / measure
- 10 U (0.1 mL)
- Frequency
- Once daily (pre-bed)
- Weekly total
- 3.5 mg/week
Weekly totals apply only during the active phase.
Titration rules
-
Standard (200 mcg pre-bed): Common research dose.
-
Cycle structure: 12–24 weeks continuous, then 4-week break. Sermorelin’s pulsatile pattern preserves natural feedback better than continuous-elevation alternatives.
-
Timing: Within 1 hour of sleep, fasted (no food/protein in last 2h).
-
GH pulse support
-
Sleep and recovery
-
Water retention
-
Injection-site reactions
Practical rules
- Pre-bed timing is the common pattern.
- Avoid food close to dosing.
- Keep sleep and training steady.
- Rotate sites.