What it is
Semax is a synthetic ACTH(4-10) analog used in Russian neuropeptide protocols.
Evidence boundary
Investigational with limited human support.
Trial evidence
- PMID 41479572 — The Potential of the Peptide Drug Semax and Its Derivative for Correcting Pathological Impairments in the Animal Model of Alzheimer’s Disease.
- PMID 41179234 — Effect of ACTH4-10Pro8-Gly9-Pro10 on anti-inflammatory cytokine (IL-4, IL-10, IL-13) expression in acute spinal cord injury models (male Sprague Dawley rats).
- PMID 42021992 — Therapeutic peptides in gerontology: mechanisms and applications for healthy aging.
Preparation and measurement
Reconstitution: 10 mg vial + 2 mL BAC = 5 mg/mL.
Concentration matches.
Reference schedule
| Phase | Dose | Draw / measure | Frequency | Weekly total |
|---|---|---|---|---|
| Weeks 1–2 (titration) | 300 mcg | 6 U (0.06 mL) | Once daily | 2.1 mg/week |
| Weeks 3–4 | 500 mcg | 10 U (0.1 mL) | Once daily | 3.5 mg/week |
| Weeks 5–6 | 600 mcg | 12 U (0.12 mL) | Once daily | 4.2 mg/week |
| Weeks 7–8 (target) | 800 mcg | 16 U (0.16 mL) | Once daily | 5.6 mg/week |
Weeks 1–2 (titration)
- Dose
- 300 mcg
- Draw / measure
- 6 U (0.06 mL)
- Frequency
- Once daily
- Weekly total
- 2.1 mg/week
Weeks 3–4
- Dose
- 500 mcg
- Draw / measure
- 10 U (0.1 mL)
- Frequency
- Once daily
- Weekly total
- 3.5 mg/week
Weeks 5–6
- Dose
- 600 mcg
- Draw / measure
- 12 U (0.12 mL)
- Frequency
- Once daily
- Weekly total
- 4.2 mg/week
Weeks 7–8 (target)
- Dose
- 800 mcg
- Draw / measure
- 16 U (0.16 mL)
- Frequency
- Once daily
- Weekly total
- 5.6 mg/week
Weekly totals apply only during the active phase.
Titration rules
- Light (300 mcg, once daily): Maintenance / cognitive support.
- Standard (600 mcg, twice daily): Common research dose.
- Cycle structure: 2–4 weeks for cognitive enhancement; 8+ weeks for stroke recovery. 2-week breaks between cycles.
- Timing: Morning dose for daytime cognitive effect. Avoid late-evening — mild stimulant effect.
Cycle length and breaks
Use 2-week breaks between cycles.
What to monitor
- Tolerability
- Headache or agitation
- Nasal irritation if used intranasally
Practical rules
- Keep the route consistent if you are comparing notes.
- Rotate sites if used subcutaneously.
Related protocols
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Availability and batch-linked COA records for Semax Peptide Protocol & Dosing are kept with the current product listing.
View availability & COA → Verification notes