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Cognitive / Nootropic

Semax Peptide Protocol & Dosing

Updated 2mo ago 6 min read 305+ helpful Calculator
Validity Score

Validity Score

17 Speculative
Evidence 22
Community 35
Completeness 71
Actionability 80
Coverage 80
Penalty -26

This score combines formal evidence, page completeness, calculator readiness, and community convergence.

What it is

Semax is a synthetic ACTH(4-10) analog used in Russian neuropeptide protocols.

Evidence boundary

Investigational with limited human support.

Trial evidence

  • PMID 41479572 — The Potential of the Peptide Drug Semax and Its Derivative for Correcting Pathological Impairments in the Animal Model of Alzheimer’s Disease.
  • PMID 41179234 — Effect of ACTH4-10Pro8-Gly9-Pro10 on anti-inflammatory cytokine (IL-4, IL-10, IL-13) expression in acute spinal cord injury models (male Sprague Dawley rats).
  • PMID 42021992 — Therapeutic peptides in gerontology: mechanisms and applications for healthy aging.

Preparation and measurement

Reconstitution: 10 mg vial + 2 mL BAC = 5 mg/mL.

Concentration matches.

Reference schedule

Reference schedule
PhaseDoseDraw / measureFrequencyWeekly total
Weeks 1–2 (titration)300 mcg6 U (0.06 mL)Once daily2.1 mg/week
Weeks 3–4500 mcg10 U (0.1 mL)Once daily3.5 mg/week
Weeks 5–6600 mcg12 U (0.12 mL)Once daily4.2 mg/week
Weeks 7–8 (target)800 mcg16 U (0.16 mL)Once daily5.6 mg/week

Weeks 1–2 (titration)

Dose
300 mcg
Draw / measure
6 U (0.06 mL)
Frequency
Once daily
Weekly total
2.1 mg/week

Weeks 3–4

Dose
500 mcg
Draw / measure
10 U (0.1 mL)
Frequency
Once daily
Weekly total
3.5 mg/week

Weeks 5–6

Dose
600 mcg
Draw / measure
12 U (0.12 mL)
Frequency
Once daily
Weekly total
4.2 mg/week

Weeks 7–8 (target)

Dose
800 mcg
Draw / measure
16 U (0.16 mL)
Frequency
Once daily
Weekly total
5.6 mg/week

Weekly totals apply only during the active phase.

Titration rules

  • Light (300 mcg, once daily): Maintenance / cognitive support.
  • Standard (600 mcg, twice daily): Common research dose.
  • Cycle structure: 2–4 weeks for cognitive enhancement; 8+ weeks for stroke recovery. 2-week breaks between cycles.
  • Timing: Morning dose for daytime cognitive effect. Avoid late-evening — mild stimulant effect.

Cycle length and breaks

Use 2-week breaks between cycles.

What to monitor

  • Tolerability
  • Headache or agitation
  • Nasal irritation if used intranasally

Practical rules

  • Keep the route consistent if you are comparing notes.
  • Rotate sites if used subcutaneously.
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Dosing references

Peptide dosage chart Peptide dose calculator Syringe mixability

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Supply & lot verification Availability and batch-linked COA records for Semax Peptide Protocol & Dosing are tracked with the current supplier listings. View availability & COA →

Dosing Calculator

10 mg + 2 mL BAC · week 1 300 mcg
LIVE CALCULATIONvolume / concentration / draw
RP–CALC–01
DRAW AMOUNT6 units0.06 mL · U-100
Draw 6 units, equivalent to 0.06 milliliters.
Concentration5 mg/mL
Selected dose0.3 mg (300 mcg) = 6 units
Enter a desired amount in milligrams or micrograms.
05 Standard amounts
1–10 mg · 0.5 mg steps
06 Suggested doses Select a row
1 unit = 0.01 mL on a U-100 syringe. Values retain decimal precision; visual marks are not silently snapped.
07 cycle summary

Vials required for Cycle

Estimate how much material you need for a full cycle, including cycle length and the number of cycles you plan to run.

Cycle total —
Total required vials —
Total reconstitution —
Total BAC water —
08 projected levels

How the draws stack up

A first-order model of depot absorption and elimination, run on the draws and cadence above. Pick the half-life from whatever your own source documents — this page does not assume one per compound. A planning sketch — not a prediction for any compound or any individual.

Half-life

Modelled level across the cycle. Each spike is one draw.

Accumulation—steady state vs one draw
Peak-to-trough—inside one interval
Steady state—about 4 half-lives
Draws modelled—at this cadence
Vial yieldat the selected amount
Draws per vial—
Lasts—
Volume used—
Limiting factor—
Water matrixsame vial, same amount
WaterStrengthDraw
0.5 mL——
1 mL——
2 mL——
3 mL——
5 mL——

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