What it is
Gonadorelin is synthetic GnRH used to stimulate pituitary LH and FSH release. It belongs in endocrine and fertility work, not generic TRT language.
Evidence boundary
Human trial evidence exists. Keep the interpretation close to fertility and endocrine use, and do not turn it into a universal restart protocol.
Trial evidence
- PMID 42348776 — Reversible congenital hypogonadotropic hypogonadism: keys for clinical management.
- PMID 42274282 — Neuroendocrine regulation of female fertility: the role of CNS-derived hormones.
- PMID 42360331 — GnRH antagonists for the treatment of fibroids and adenomyosis, current evidence and future perspectives.
Preparation and measurement
Reconstitution: 10 mg vial + 10 mL BAC = 1 mg/mL.
Concentration matches.
Reference schedule
| Phase | Dose | Draw / measure | Frequency | Weekly total |
|---|---|---|---|---|
| Example step 1 | 50 mcg | 5 U (0.05 mL) | 2–3× weekly | 100–150 mcg/week |
| Example step 2 | 100 mcg | 10 U (0.1 mL) | 2–3× weekly | 200–300 mcg/week |
| Example step 3 | 125 mcg | 12.5 U (0.125 mL) | 2–3× weekly | 250–375 mcg/week |
Example step 1
- Dose
- 50 mcg
- Draw / measure
- 5 U (0.05 mL)
- Frequency
- 2–3× weekly
- Weekly total
- 100–150 mcg/week
Example step 2
- Dose
- 100 mcg
- Draw / measure
- 10 U (0.1 mL)
- Frequency
- 2–3× weekly
- Weekly total
- 200–300 mcg/week
Example step 3
- Dose
- 125 mcg
- Draw / measure
- 12.5 U (0.125 mL)
- Frequency
- 2–3× weekly
- Weekly total
- 250–375 mcg/week
Weekly totals apply only during the active phase. These are reference rows, not a universal treatment plan.
Titration rules
- 100 mcg 2–3× weekly is the common practical bolus step.
- Keep the dosing pattern consistent.
- Pulsatile pump dosing is more physiological but less practical.
- No single escalation sequence fits every use case.
Cycle length and breaks
Reassess every 8–12 weeks.
What to monitor
- LH and FSH response
- Testosterone or estradiol response depending on use case
- Injection-site reactions
- Do not frame this in generic TRT language.
Practical rules
- Keep bloodwork in the loop.
- Use a consistent injection pattern.
- Rotate sites.