What it is
HMG is a gonadotropin mixture with FSH and LH activity. It belongs in fertility treatment and is usually paired with HCG when the goal is spermatogenesis or ovarian stimulation.
Evidence boundary
Human trial evidence and licensed products exist. Keep this as prescription fertility care, not a general peptide cycle.
Trial evidence
- PMID 30648738 — Gonadotrophins for ovulation induction in women with polycystic ovary syndrome.
- PMID 20389096 — Clinical efficacy of highly purified hMG versus recombinant FSH in IVF/ICSI cycles: a meta-analysis.
- PMID 38981692 — Investigational Treatment of Congenital Hypogonadotropic Hypogonadism in Infants.
Preparation and measurement
Reconstitution: 10 mg vial + 2 mL BAC = 5 mg/mL.
Concentration matches.
Reference schedule
| Phase | Dose | Draw / measure | Frequency | Weekly total |
|---|---|---|---|---|
| Clinician-directed reference phase | 75 IU | 1.00 mL from a 75 IU/mL preparation | 3 times weekly | 225 IU/week |
Clinician-directed reference phase
- Dose
- 75 IU
- Draw / measure
- 1.00 mL from a 75 IU/mL preparation
- Frequency
- 3 times weekly
- Weekly total
- 225 IU/week
Weekly totals apply only during the active phase.
Titration rules
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There is no universal self-directed titration.
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Dose changes depend on labs and the treatment goal.
-
The source schedule holds 75 IU per administration.
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FSH and LH coverage for fertility induction
-
Response when paired with HCG
-
Injection-site reactions
-
Ovarian hyperstimulation risk in female cycles
Practical rules
- Keep bloodwork in the loop.
- Use the route prescribed for the indication.
- Rotate injection sites.