Kisspeptin Peptide Protocol & Dosing

What it is

Kisspeptin is a hypothalamic neuropeptide upstream of GnRH and the HPG axis. It is studied in fertility and reproductive signaling.

Evidence boundary

Investigational with human trial data.

Trial evidence

• PMID 24615662 — The kisspeptin-GnRH pathway in human reproductive health and disease.
• PMID 34410262 — Beyond GnRH, LH and FSH: The role of kisspeptin on hypothalalmic-pituitary gonadal (HPG) axis pathology and diagnostic consideration.
• PMID 40598808 — Evaluation and Treatment of Patients With Hypothalamic Hypogonadism.
• PMID 42707558 — Structural basis for Kisspeptin-10 selectivity toward KISS1R: computational insights.
• PMID 42663893 — Follicular kisspeptin-VEGF axis in polycystic ovary syndrome and ovarian hyperstimulation syndrome.

Preparation and measurement

Reconstitution: 10 mg vial + 2 mL BAC = 5 mg/mL.

Concentration matches.

Reference schedule

Weekly totals apply only during the active phase. These are research rows, not a universal stimulation protocol.

Titration rules

• 50–100 mcg is the conservative start.

• 100–200 mcg is the common practical range in collected notes.

• Keep the schedule tied to the fertility goal.

• No universal escalation sequence fits every use case.

• LH and FSH response

• Reproductive context and timing

• Injection-site reactions

• Do not market this as a libido hack.

Practical rules

• Keep bloodwork in the loop.
• Use a consistent injection pattern.
• Rotate sites.