What it is
Kisspeptin is a hypothalamic neuropeptide upstream of GnRH and the HPG axis. It is studied in fertility and reproductive signaling.
Evidence boundary
Investigational with human trial data.
Trial evidence
- PMID 24615662 — The kisspeptin-GnRH pathway in human reproductive health and disease.
- PMID 34410262 — Beyond GnRH, LH and FSH: The role of kisspeptin on hypothalalmic-pituitary gonadal (HPG) axis pathology and diagnostic consideration.
- PMID 40598808 — Evaluation and Treatment of Patients With Hypothalamic Hypogonadism.
- PMID 42707558 — Structural basis for Kisspeptin-10 selectivity toward KISS1R: computational insights.
- PMID 42663893 — Follicular kisspeptin-VEGF axis in polycystic ovary syndrome and ovarian hyperstimulation syndrome.
Preparation and measurement
Reconstitution: 10 mg vial + 2 mL BAC = 5 mg/mL.
Concentration matches.
Reference schedule
| Phase | Dose | Draw / measure | Frequency | Weekly total |
|---|---|---|---|---|
| Conservative start | 50 mcg | 1 U (0.01 mL) | Once daily | 350 mcg/week |
| Common research range | 100 mcg | 2 U (0.02 mL) | Once daily | 700 mcg/week |
| Higher research range | 200 mcg | 4 U (0.04 mL) | Once daily | 1.4 mg/week |
Conservative start
- Dose
- 50 mcg
- Draw / measure
- 1 U (0.01 mL)
- Frequency
- Once daily
- Weekly total
- 350 mcg/week
Common research range
- Dose
- 100 mcg
- Draw / measure
- 2 U (0.02 mL)
- Frequency
- Once daily
- Weekly total
- 700 mcg/week
Higher research range
- Dose
- 200 mcg
- Draw / measure
- 4 U (0.04 mL)
- Frequency
- Once daily
- Weekly total
- 1.4 mg/week
Weekly totals apply only during the active phase. These are research rows, not a universal stimulation protocol.
Titration rules
-
50–100 mcg is the conservative start.
-
100–200 mcg is the common practical range in collected notes.
-
Keep the schedule tied to the fertility goal.
-
No universal escalation sequence fits every use case.
-
LH and FSH response
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Reproductive context and timing
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Injection-site reactions
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Do not market this as a libido hack.
Practical rules
- Keep bloodwork in the loop.
- Use a consistent injection pattern.
- Rotate sites.
Related protocols
Gonadorelin Peptide Protocol & DosingPT-141 (Bremelanotide) Peptide Protocol & DosingHCG Peptide Protocol & DosingOxytocin Peptide Protocol & DosingVIP Peptide Protocol & Dosing Supply & lot verification
Availability and batch-linked COA records for Kisspeptin Peptide Protocol & Dosing are kept with the current product listing.
View availability & COA → Verification notes