What it is
Melanotan II is a melanocortin analog studied for pigmentation, appetite effects, and sexual arousal research.
Evidence boundary
Investigational with limited human evidence. Keep the interpretation conservative and cosmetic-focused.
Trial evidence
- PMID 23774329 — The melanocortin-4 receptor as target for obesity treatment: a systematic review of emerging pharmacological therapeutic options.
Preparation and measurement
Reconstitution: 10 mg vial + 2 mL BAC = 5 mg/mL.
Concentration matches.
Reference schedule
| Phase | Dose | Draw / measure | Frequency | Weekly total |
|---|---|---|---|---|
| Week 1 (titration) | 250 mcg | 5 U (0.05 mL) | Once daily (loading) → 1–2× weekly (maintenance) | 250–500 mcg/week |
| Week 2 | 500 mcg | 10 U (0.1 mL) | Once daily (loading) → 1–2× weekly (maintenance) | 0.5–1 mg/week |
| Week 3 | 750 mcg | 15 U (0.15 mL) | Once daily (loading) → 1–2× weekly (maintenance) | 0.75–1.5 mg/week |
| Weeks 4–8 (target) | 1 mg | 20 U (0.2 mL) | Once daily (loading) → 1–2× weekly (maintenance) | 1–2 mg/week |
| Weeks 9+ (maintenance) | 1 mg | 20 U (0.2 mL) | Once daily (loading) → 1–2× weekly (maintenance) | 1–2 mg/week |
Week 1 (titration)
- Dose
- 250 mcg
- Draw / measure
- 5 U (0.05 mL)
- Frequency
- Once daily (loading) → 1–2× weekly (maintenance)
- Weekly total
- 250–500 mcg/week
Week 2
- Dose
- 500 mcg
- Draw / measure
- 10 U (0.1 mL)
- Frequency
- Once daily (loading) → 1–2× weekly (maintenance)
- Weekly total
- 0.5–1 mg/week
Week 3
- Dose
- 750 mcg
- Draw / measure
- 15 U (0.15 mL)
- Frequency
- Once daily (loading) → 1–2× weekly (maintenance)
- Weekly total
- 0.75–1.5 mg/week
Weeks 4–8 (target)
- Dose
- 1 mg
- Draw / measure
- 20 U (0.2 mL)
- Frequency
- Once daily (loading) → 1–2× weekly (maintenance)
- Weekly total
- 1–2 mg/week
Weeks 9+ (maintenance)
- Dose
- 1 mg
- Draw / measure
- 20 U (0.2 mL)
- Frequency
- Once daily (loading) → 1–2× weekly (maintenance)
- Weekly total
- 1–2 mg/week
Weekly totals apply only during the active phase.
Titration rules
- Loading + maintenance pattern:
- Day 1–3: 0.25 mg daily (lowest tolerated dose).
- Day 4–14: 0.5 mg daily (loading).
- Maintenance (week 3+): 1 mg, 1–2× weekly to maintain pigmentation.
- Cycle: Continuous with monthly skin checks. An alternative schedule uses 12 weeks on, 4 weeks off.
Cycle length and breaks
An alternative schedule uses 12 weeks on, 4 weeks off.
What to monitor
- Pigmentation response
- Nausea and flushing
- Moles and freckles
- Libido or appetite changes if that is the actual goal
- Injection-site reactions
Practical rules
- Use sunscreen.
- Check skin changes.
- Rotate sites.
- Keep the interpretation clearly investigational.
Related protocols
PT-141 (Bremelanotide) Peptide Protocol & DosingGHK-Cu Peptide Protocol & DosingSnap-8 Peptide Protocol & DosingMelanotan I Peptide Protocol & Dosing Supply & lot verification
Availability and batch-linked COA records for Melanotan II Peptide Protocol & Dosing are kept with the current product listing.
View availability & COA → Verification notes