What it is
Tesamorelin is a GHRH analog with human evidence for a specific indication. Ipamorelin is a selective ghrelin-receptor agonist. A fixed blend combines them in one draw, but the blend itself does not have an authoritative protocol.
Evidence boundary
Blend note only. Tesamorelin has human evidence for a specific indication; the fixed 1:1 tesamorelin/ipamorelin blend does not have a validated titration.
Preparation and measurement
Reconstitution: 10 mg vial + 2 mL BAC = 5 mg/mL.
Concentration matches.
Reference schedule
| Phase | Dose | Draw / measure | Frequency | Weekly total |
|---|---|---|---|---|
| Conversion row — not a titration step | 0.167 mg total (≈83 mcg each) | 3.333 U (0.033 mL) | Not assigned | Not fixed |
| Conversion row — not a titration step | 0.333 mg total (≈167 mcg each) | 6.667 U (0.067 mL) | Not assigned | Not fixed |
| Conversion row — not a titration step | 0.667 mg total (≈333 mcg each) | 13.333 U (0.133 mL) | Not assigned | Not fixed |
Conversion row — not a titration step
- Dose
- 0.167 mg total (≈83 mcg each)
- Draw / measure
- 3.333 U (0.033 mL)
- Frequency
- Not assigned
- Weekly total
- Not fixed
Conversion row — not a titration step
- Dose
- 0.333 mg total (≈167 mcg each)
- Draw / measure
- 6.667 U (0.067 mL)
- Frequency
- Not assigned
- Weekly total
- Not fixed
Conversion row — not a titration step
- Dose
- 0.667 mg total (≈333 mcg each)
- Draw / measure
- 13.333 U (0.133 mL)
- Frequency
- Not assigned
- Weekly total
- Not fixed
Weekly totals apply only during the active phase.
Titration rules
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A 1:1 fixed-ratio blend cannot reproduce the usual standalone tesamorelin-to-ipamorelin dose ratio. Every increase raises both components equally.
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The table reports exactly what the fixed volume delivers. It is a product-math table, not proof that the combination has a clinically validated titration.
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If an exact tesamorelin dose and a much smaller ipamorelin dose are required, separate vials are the only precise approach.
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Whether the blend is being treated as a finished standard
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Injection-site reactions
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Component exposure, since the fixed ratio changes both at once
Practical rules
- Do not use this as proof that the combo is validated.
- Rotate sites if the blend is being compared in notes.