Sleep / Circadian

DSIP Peptide Protocol & Dosing

Updated 3mo ago 8 min read 267+ helpful Calculator

Validity Score

17 Speculative

Evidence 42

Community 35

Completeness 71

Actionability 80

Coverage 60

Penalty -34

This score combines formal evidence, page completeness, calculator readiness, and community convergence.

What it is

DSIP is a small neuropeptide discussed in older sleep and stress-recovery literature. The evidence base is limited and dated.

Evidence boundary

Weak / limited evidence. Treat this as a research note, not a validated sleep protocol.

Trial evidence

PMID 8008641 — Neuroactive peptides: unique phases in research on mammalian brain over three decades.
PMID 25805003 — Peptides and the blood-brain barrier.

Preparation and measurement

Reconstitution: 5 mg vial + 3 mL BAC = 1.67 mg/mL.

Concentration matches.

Reference schedule

Reference schedule
Phase	Dose	Draw / measure	Frequency	Weekly total
Week 1 (titration)	100 mcg	6 U (0.06 mL)	Pre-bedtime	700 mcg/week
Week 2	150 mcg	9 U (0.09 mL)	Pre-bedtime	1.05 mg/week
Week 3	200 mcg	12 U (0.12 mL)	Pre-bedtime	1.4 mg/week
Weeks 4–8 (target)	275 mcg	16.5 U (0.165 mL)	Pre-bedtime	1.925 mg/week

Week 1 (titration)

Dose: 100 mcg
Draw / measure: 6 U (0.06 mL)
Frequency: Pre-bedtime
Weekly total: 700 mcg/week

Week 2

Dose: 150 mcg
Draw / measure: 9 U (0.09 mL)
Frequency: Pre-bedtime
Weekly total: 1.05 mg/week

Week 3

Dose: 200 mcg
Draw / measure: 12 U (0.12 mL)
Frequency: Pre-bedtime
Weekly total: 1.4 mg/week

Weeks 4–8 (target)

Dose: 275 mcg
Draw / measure: 16.5 U (0.165 mL)
Frequency: Pre-bedtime
Weekly total: 1.925 mg/week

Weekly totals apply only during the active phase.

Titration rules

Starting (100 mcg): Conservative starting dose.
Standard (200 mcg): Common research dose.
Timing: 30–60 min before bedtime in a calm setting. Avoid screens, caffeine, alcohol within 2h of dosing.
Sleep onset and sleep continuity
Next-day grogginess
Injection-site discomfort

Practical rules

Keep bedtime consistent if used at all.
Do not push this as a proven sleep fix.
Use simple sleep hygiene alongside it.
Subcutaneous, rotate sites if dosing nightly.

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Dosing references

Peptide dosage chart Peptide dose calculator Syringe mixability

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Dosing Calculator

10 mg + 2 mL BAC · week 1 100 mcg

LIVE CALCULATIONvolume / concentration / draw

RP–CALC–01

01 Vial size

02 BAC water

DRAW AMOUNT2 units0.02 mL · U-100

Draw 2 units, equivalent to 0.02 milliliters.

Concentration5 mg/mL

Selected dose0.1 mg (100 mcg) = 2 units

04 Custom dose

05 Standard amounts

1–10 mg · 0.5 mg steps

06 Suggested doses Select a row

1 unit = 0.01 mL on a U-100 syringe. Values retain decimal precision; visual marks are not silently snapped.

07 cycle summary

Vials required for Cycle

Estimate how much material you need for a full cycle, including cycle length and the number of cycles you plan to run.

Cycle length (weeks) Injections per week Number of cycles

Cycle total —

Total required vials —

Total reconstitution —

Total BAC water —

08 projected levels

How the draws stack up

A first-order model of depot absorption and elimination, run on the draws and cadence above. Pick the half-life from whatever your own source documents — this page does not assume one per compound. A planning sketch — not a prediction for any compound or any individual.

Half-life

Hours

Modelled level across the cycle. Each spike is one draw.

Accumulation—steady state vs one draw

Peak-to-trough—inside one interval

Steady state—about 4 half-lives

Draws modelled—at this cadence

Vial yieldat the selected amount

Draws per vial—

Lasts—

Volume used—

Limiting factor—

Water matrixsame vial, same amount

WaterStrengthDraw

0.5 mL——

1 mL——

2 mL——

3 mL——

5 mL——