What it is
DSIP is a small neuropeptide discussed in older sleep and stress-recovery literature. The evidence base is limited and dated.
Evidence boundary
Weak / limited evidence. Treat this as a research note, not a validated sleep protocol.
Trial evidence
- PMID 8008641 — Neuroactive peptides: unique phases in research on mammalian brain over three decades.
- PMID 25805003 — Peptides and the blood-brain barrier.
Preparation and measurement
Reconstitution: 5 mg vial + 3 mL BAC = 1.67 mg/mL.
Concentration matches.
Reference schedule
| Phase | Dose | Draw / measure | Frequency | Weekly total |
|---|---|---|---|---|
| Week 1 (titration) | 100 mcg | 6 U (0.06 mL) | Pre-bedtime | 700 mcg/week |
| Week 2 | 150 mcg | 9 U (0.09 mL) | Pre-bedtime | 1.05 mg/week |
| Week 3 | 200 mcg | 12 U (0.12 mL) | Pre-bedtime | 1.4 mg/week |
| Weeks 4–8 (target) | 275 mcg | 16.5 U (0.165 mL) | Pre-bedtime | 1.925 mg/week |
Week 1 (titration)
- Dose
- 100 mcg
- Draw / measure
- 6 U (0.06 mL)
- Frequency
- Pre-bedtime
- Weekly total
- 700 mcg/week
Week 2
- Dose
- 150 mcg
- Draw / measure
- 9 U (0.09 mL)
- Frequency
- Pre-bedtime
- Weekly total
- 1.05 mg/week
Week 3
- Dose
- 200 mcg
- Draw / measure
- 12 U (0.12 mL)
- Frequency
- Pre-bedtime
- Weekly total
- 1.4 mg/week
Weeks 4–8 (target)
- Dose
- 275 mcg
- Draw / measure
- 16.5 U (0.165 mL)
- Frequency
- Pre-bedtime
- Weekly total
- 1.925 mg/week
Weekly totals apply only during the active phase.
Titration rules
-
Starting (100 mcg): Conservative starting dose.
-
Standard (200 mcg): Common research dose.
-
Timing: 30–60 min before bedtime in a calm setting. Avoid screens, caffeine, alcohol within 2h of dosing.
-
Sleep onset and sleep continuity
-
Next-day grogginess
-
Injection-site discomfort
Practical rules
- Keep bedtime consistent if used at all.
- Do not push this as a proven sleep fix.
- Use simple sleep hygiene alongside it.
- Subcutaneous, rotate sites if dosing nightly.
Related protocols
Pinealon Peptide Protocol & DosingEpitalon Peptide Protocol & DosingMelanotan II Peptide Protocol & Dosing Supply & lot verification
Availability and batch-linked COA records for DSIP Peptide Protocol & Dosing are kept with the current product listing.
View availability & COA → Verification notes