What it is
Epitalon is a synthetic tetrapeptide from pineal-extract work.
Evidence boundary
Regional / investigational.
Trial evidence
- PMID 40908429 — Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.
- PMID 40493162 — The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an In Vitro Model of Diabetic Retinopathy.
- PMID 40141333 — Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.
- PMID 42021992 — Therapeutic peptides in gerontology: mechanisms and applications for healthy aging.
Preparation and measurement
Reconstitution: 10 mg vial + 1 mL BAC = 10 mg/mL.
Concentration matches.
Reference schedule
| Phase | Dose | Draw / measure | Frequency | Weekly total |
|---|---|---|---|---|
| Microgram protocol, active days 1–10 | 100–500 mcg | 1–5 U (0.01–0.05 mL) | Once daily | 0.7–3.5 mg/week while active |
| Microgram protocol, days 11–30 | 0 | 0 U (no draw) | Off | 0 |
| Classic protocol | 5 mg | 50 U (0.5 mL) | Once daily for 10–20 days | 35 mg/week while active |
| Classic high-dose variant | 10 mg | 100 U (1 mL) | Once daily for 10 days | 70 mg/week while active |
Microgram protocol, active days 1–10
- Dose
- 100–500 mcg
- Draw / measure
- 1–5 U (0.01–0.05 mL)
- Frequency
- Once daily
- Weekly total
- 0.7–3.5 mg/week while active
Microgram protocol, days 11–30
- Dose
- 0
- Draw / measure
- 0 U (no draw)
- Frequency
- Off
- Weekly total
- 0
Classic protocol
- Dose
- 5 mg
- Draw / measure
- 50 U (0.5 mL)
- Frequency
- Once daily for 10–20 days
- Weekly total
- 35 mg/week while active
Classic high-dose variant
- Dose
- 10 mg
- Draw / measure
- 100 U (1 mL)
- Frequency
- Once daily for 10 days
- Weekly total
- 70 mg/week while active
Weekly totals apply only during the active phase.
Titration rules
- These are separate protocol families, not steps in one escalation.
- The microgram protocol uses 100–500 mcg for 10 days, then 20 days off.
- The classic protocol uses 5–10 mg/day for 10–20 days and is repeated only once or twice per year.
Cycle length and breaks
Do not mix milligram and microgram rows within the same cycle.
What to monitor
- Telomere / telomerase claims in the literature
- Circadian and sleep-related claims
- Tolerability
- Injection-site reactions
Practical rules
- Do not present the dose question as validated.
- Rotate sites if it is being compared in notes.
Related protocols
SS-31 (Elamipretide) Peptide Protocol & DosingMOTS-c Peptide Protocol & DosingNAD+ Protocol & DosingPinealon Peptide Protocol & DosingHumanin Peptide Protocol & Dosing Supply & lot verification
Availability and batch-linked COA records for Epitalon Peptide Protocol & Dosing are kept with the current product listing.
View availability & COA → Verification notes